Schneider-Stock, R., Ghantous, A., Gandesiri, M., Saikali, M. and Darwiche, N. Epigenetic mechanisms of plant-derived anticancer drugs. Submitted to Frontiers in Bioscience.
Darwiche, N, Sinjab, A., Abou-Lteif, G., Bou Chedid, M., Hermine, O., Dbaibo, G., and Bazarbachi, A. Inhibition of mTOR signaling by everolimus induces senescence in HTLV-associated adult T-Cell leukemia/lymphoma and apoptosis in peripheral T-cell lymphomas. In press International Journal of Cancer.
Darwiche, N. and El-Sabban, M. Research highlights: Pharmacogenetics of artesunate in cancer therapy. In press Pharmacogenomics.
Ghantous, A., Gali-Muhtasib H., Vuorela, H., Saliba, N. and Darwiche, N. What made sesquiterpene lactones reach cancer clinical trials? Drug Discovery Today: 15(15-16):668-678, 2010.
Ghantous, A., Nasser, N., Saab, I., Darwiche, N. and Saliba,N. Structure-biological activity relationship of seco-tanapartholides isolated from Achillea falcata for inhibition of HaCaT cell growth. European Journal of Medicinal Chemistry. 44(9): 3794-3797, 2009.
Ghantous, A., Abou Tayyoun, A., Abou Lteif, G., Saliba, N., Gali-Muhtasib, H., El-Sabban, M. and Darwiche N. Purified Salograviolide A isolated from Centaurea ainetensis causes growth inhibition and apoptosis in neoplastic epidermal cells. International Journal of Oncology 4: 841-849, 2008.
El-Najjar, N., Dakdouki, S., Darwiche, N., El-Sabban, M., Saliba, N. and Gali-Muhtasib, H. Anti- colon cancer effects of Salograviolide A isolated from Centaurea ainetensis. Oncology Reports 4: 897-904, 2008.
Darwiche, N., El-Banna, S. and Gali-Muhtasib, H. Cell cycle modulatory and apoptotic effects of plant-derived anticancer drugs in clinical use or development. Expert Opinion on Drug Discovery 3: 361-379, 2007 .
Darwiche, N., Ryscavage, A., Perez-Lorenzo, R., Nolan, L., Bae D. S., Hennings, H., Yuspa, S. H. and Glick A.B. Expression profiles of skin papillomas with high cancer risk display a unique genetic signature that clusters with squamous cell carcinomas and predicts risk for malignant conversion. Oncogene 26:6885-6895, 2007.
Glick A.B., Ryscavage, A., Perez-Lorenzo, R., Hennings, H., Yuspa, S. H. and Darwiche, N. The High-Risk Benign Tumor: Evidence from the Two-Stage Skin Cancer Model and Relevance for Human Cancer. Molecular Carcinogenesis 46: 605-610, 2007.
Dbaibo, G., Kfoury, Y., Darwiche, N., Panjarian, S., Kozhaya, L., Abdallah, M., El-Sabban, M., Hermine, O., de Th, H. and Bazarbachi, A. Arsenic trioxide induces de novo ceramide synthesis and inhibits glucosylceramide synthase activity to produce accumulation of cytotoxic levels of ceramide in acute promyelocytic leukemia and Adult T-Cell Leukemia/Lymphoma derived cells. Heamatologica 92: 753-762, 2007.
Darwiche, N., Abou-Lteif, G. and Ali Bazarbachi. Reactive oxygen species mediate HPR-induced cell death in malignant T cells and are Inhibited by the HTLV-I oncoprotein Tax. Leukemia 21: 261-269, 2007.
Darwiche, N., Abou-Lteif, G., Najdi, T., Kozhaya, L., Abou Tayyoun, A., Bazarbachi, A. and Dbaibo, G. Human T-cell lymphotropic virus type I-transformed T cells have a partial defect in ceramide synthesis in response to N-(4-hydroxyphenyl)retinamide. The Biochemical Journal 392: 231-239, 2005.
Darwiche, N., Bazzi, H., El-Touni, L., Abou-Lteif, G., Doueiri, Rami., Maalouf, S. and Gali-Muhtasib, H. Regulation of ultraviolet B radiation-mediated activation of AP-1 signaling by retinoids in primary keratinocytes. Radiation Research 163: 296-306, 2005.
Kabbout, M., Hatoum, A., Abou-Lteif, G., Chakroun, I., Homaidan, F. and Darwiche, N. Stage-specific effect of N-(4-hydroxyphenyl) retinamide on cell growth in squamous cell carcinogenesis. Molecular Carcinogenesis 40: 12-23, 2004.
Gali-Muhtasib H. U., Abou Kheir, W. G., Kheir, L. A., Darwiche, N. and Crooks, P.A. Molecular pathway for Thymoquinone-induced cell-cycle arrest and apoptosis in neoplastic keratinocytes. Anticancer Drugs 15 (4): 389-399, 2004.
Darwiche, N., Hatoum, A., Dbaibo, G., Kadara, H., Nasr, N., Abou-Lteif, G., Bazzi, R., Hermine, O., de Th, H. and Bazarbachi, A. N-(4-hydroxyphenyl)retinamide induces growth arrest and apoptosis in HTLV-I transformed cells. Leukemia 18: 607-615, 2004.