Department of Biology - FAS, AUB
 
Dr. Hala Mohtaseb's Publications 

Poehlmann A, Habold C, Walluscheck D, Reissing K, Bajbouj K, Ullrich O, Hartig R, Gali-Muhtasib H, Diestel A, Roessner A, and Regine Schneider Stock. Cutting edge: CHK1 directs mitotic catastrophe and senescence in oxidative-damaged colorectal cancer cells. J Cell Mol Med. 2010 Aug 16. [Epub ahead of print].

Hassan SB, Gali-Muhtasib H, Göransson H, Larsson R. Alpha terpineol: a potential anticancer agent which acts through suppressing NF-kappaB signalling. Anticancer Res. 2010 Jun;30(6):1911-1919.

Ghantous A, Gali-Muhtasib H, Vuorela H, Saliba N, Darwiche N. What made sesquiterpene lactones reach cancer clinical trials? Drug Discov Today. 2010 Aug;15(15-16):668-78. Epub 2010 Jun 9.60.  

El-Najjar N, Chatila M, Mokaddam H, Vuorela H, Ocker M, Gandesiri M, Schneider-Stock R, and *Gali-Muhtasib H. 2010. Reactive oxygen species mediate thymoquinone-induced apoptosis and activate ERK and JNK signalling. Apoptosis 15(2):183-95.

Haykal J, Geara F, Haddadin M, Smith C, Gali-Muhtasib H.U. The radiosensitizer 2-benzoyl-3-phenyl-6,7-dichloroquinoxaline 1,4-dioxide induces DNA damage in EMT-6 mammary carcinoma cells. Radiation Oncology, 2009, 4:25.

Amin A, Gali-Muhtasib H.U., Ocker M, Schneider-Stock R. 2009. Overview of Major Classes of Plant-derived Anticancer Drugs. International Journal of Biomedical Science 5(1):1-11.

Itani W, El-Banna S, Hassan S, Larsson R, Bazarbachi A, *Gali-Muhtasib H. Anti-Colon-Cancer  Components from Lebanese Sage (Salvia libanotica) Essential Oil: Mechanistic Basis.  Cancer Biology and Therapy, 2008 Nov 5;7(11). 

Gali-Muhtasib H , Kuester D, Mawrin C, Bajbouj K, Diestel A, Ocker M, Habold C, Foltzer-Jourdainne C, Schoenfeld P, Peters B, Diab-Assaf M, Pommrich U, Itani W, Lippert H, Roessner A, Schneider-Stock R.. 2008. Thymoquinone triggers inactivation of the stress response pathway sensor CHEK1 and contributes to apoptosis in colorectal cancer cells, Cancer Research, 68(14):5609-18.

*Gali-Muhtasib H , Ocker M, Kuester D, Krueger S, Evert M, El-Hajj Z, Diestel A, El-Najjar N, Peters B, Jurjus A, Roessner A and Schneider-Stock R. 2008. Thymoquinone inhibits invasion of mouse colon tumor cells and growth of murine colon cancer models. Journal of Cellular and Molecular Medicine, 12(1):330-42.

El-Najjar N, Dakdouki S, Darwiche N, El-Sabban M, Saliba N and
* Gali-Muhtasib H . 2008. Anti-colon cancer effects of Salograviolide A isolated from Centaurea ainetensis. Oncology Reports,19(4):897-904.

Haykal J, Fernainy P, Itani W, Haddadin M, Geara F, Smith C,
* Gali-Muhtasib H . 2008.  Radiosensitization of EMT6 mammary carcinoma cells by 2-benzoyl-3-phenyl-6,7-dichloroquinoxaline 1,4-dioxide. Radiother Oncol. 86(3):412-8. Epub 2007 Nov 19.

Ghantous A, Abou Tayyoun A, Abou Lteif G, Saliba N,
Gali-Muhtasib H , El-Sabban M, Darwiche N. 2008. Purified Salograviolide A isolated from Centaurea ainetensis causes growth inhibition and apoptosis in neoplastic epidermal cells. International Journal of Oncology, 32(4):841-9.

Darwiche N, El-Banna S, and *Gali-Muhtasib, H. 2007. Cell cycle modulatory and apoptotic effects of plant-derived anticancer drugs in clinical use or development. Expert Opinion on Drug Discovery, 2(3):361-379.

El-Najjar N, Saliba N, Talhouk S and *Gali-Muhtasib H. 2007. Onopordum cynarocephalum induces apoptosis and protects against 1,2 dimethylhydrazine-induced colon cancer. Oncology Reports 17(6):1517-23.

Roepke M, Diestel A, Bajbouj K, Walluscheck D, Schonfeld P, Roessner A, Schneider-Stock R, Gali-Muhtasib H. 2007. Lack of p53 Augments Thymoquinone-Induced Apoptosis and Caspase Activation in Human Osteosarcoma Cells. Cancer Biology and Therapy 6(2):160-169.

Itani W, Geara F, Haykal J, Haddadin M, Gali-Muhtasib H. 2007. Radiosensitization by 2-benzoyl-3-phenyl-6,7-dichloroquinoxaline 1,4-dioxide under oxia and hypoxia in human colon cancer cells. Radiation Oncology 2:1.

Al-Ayyoubi S, Gali-Muhtasib H. 2007. Differential apoptosis by gallotannin in human colon cancer cells with distinct p53 status. Molecular Carcinogenesis 46(3):176-86.

 Gali-Muhtasib H, Roessner A, Schneider-Stock R. 2006. Thymoquinone: a promising anti-cancer drug from natural sources. International Journal of Biochemistry and Cell Biology 38(8):1249-53

Darwiche N, Bazzi H, El-Touni L, Abou-Lteif G, Doueiri R, Hatoum A, Maalouf S, Gali-Muhtasib H. 2005. Regulation of ultraviolet B radiation-mediated activation of AP-1 signaling by retinoids in primary keratinocytes. Radiation Research, 163(3):296-306.

Schneider-Stock R, Diab-Assef M, Rohrbeck A, Boltze C, Hartig R, Schnfeld B, Roessner A, Gali-Muhtasib, H. 2005. 5-AZA-cytidine is a potent inhibitor of DNA methyltransferase 3a and induces apoptosis in HCT116 colon cancer cells via Gadd45- and p53-Dependent Mechanisms. Journal of Pharmacology and Experimental Therapeutics, 312(2):525-536.

Gali-Muhtasib H.U., Diab-Assaf M. and Haddadin M.J. 2005. Quinoxaline 1,4- dioxides Induce Cell Cycle Arrest, Apoptosis and changes in transforming growth factors and Extracellular signal-regulated kinase expression in Human colon cancer cells. Cancer Chemotherapy and Pharmacology, 55(4):369-378.

Gali-Muhtasib H, Diab-Assaf M, Boltze C, Al-Hmaira J, Hartig R, Roessner A and Schneider-Stock R. 2004. Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53-dependent mechanism. International Journal of Oncology 25(4), 857-866.

Harakeh S, Diab-Assef M, El-Sabban M, Haddadin M, Gali-Muhtasib H. 2004. Inhibition of proliferation and induction of apoptosis by 2-benzoyl-3-phenyl-6,7- dichloroquinoxaline 1,4-dioxide in adult T cell leukemia cells. Chemico-Biological Interactions 148(3), 101-113.

Gali-Muhtasib H.U., Aboukheir W., Kheir L., Darwiche N., Crooks P. 2004. Molecular pathway for Thymoquinone-induced cell cycle arrest and apoptosis in neoplastic keratinocytes. Anticancer Drugs 15 (4), 389-399.

Gali-Muhtasib H.U., Sidani M., Geara F., Assaf-Diab M., Al-Hmaira J., Haddadin M.J., Zaatari G. 2004. Quinoxaline 1,4-dioxides are Novel Angiogenesis Inhibitors that Potentiate Antitumor Effects of Ionizing Radiation. International Journal of Oncology 24, 1121-1131.

Gali-Muhtasib, H.U. and Bakkar, N. 2002. Modulating Cell Cycle: Current Applications and Prospects for Future Drug Development. Current Cancer Drug Targets 2: 309-336.

Gali-Muhtasib, H.U., Diab-Assef, M, and Haddadin, M.J. 2002. Hypoxic cells in tumors as a target for cancer therapy. Lebanese Medical Journal 50 (4): 175-179.

Maalouf, S., El-Sabban, M., Darwiche, N. and Gali-Muhtasib, H.U. 2002. Protective effect of vitamin E on ultraviolet B light-induced damage in keratinocytes. Molecular Carcinogenesis 34: 121-130.

Diab-Assaf, M., Haddadin, M.J., Yared, P., Al-Assaad., C., and Gali-Muhtasib, H.U. 2002. Quinoxaline 1,4-dioxides: hypoxia selective therapeutic agents. Molecular carcinogenesis 33 (4): 198-205.

Farhat, G., Affara, N. and Gali-Muhtasib, H.U. 2001. Seasonal changes in the composition of the essential oil extract of East Mediterranean Sage (Salvia libanotica) and its toxicity in mice. Toxicon 39: 1601-1605.

Gali-Muhtasib, H.U., Haddadin, M.J., Rahhal, D.N. and Younes, I. 2001. Quinoxaline 1,4-dioxides as anticancer and hypoxia-selective drugs. Oncology Reports 8: 679-684.

Gali-Muhtasib, H.U., Younis, I., Karchesy, J. and El-Sabban, M. 2001. Plant tannins inhibit the induction of aberrant crypt foci and colonic tumors by 1,2-dimethyl hydrazine in mice. Nutrition and Cancer 39: 108-116.  



 

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