American Univesity of Beirut

T1/T2 ratio: A quantitative sensitive marker of brain tissue integrity in multiple sclerosis

In this paper​ we validate the use of the T1/T2 ratio as a sensitive marker for white matter (WM) abnormalities in Multiple Sclerosis (MS). This was done by assessing WM integrity by diffusion tensor imaging and comparing the obtained results to the new T1/T2 ratio in a group of relapsing remitting MS (RRMS) patients and a group of healthy control (HC) subjects. Results showed significant differences between RRMS and HC in both DTI and T1/T2 ratio measurements. T1/T2 ratio even demonstrated extensive WM abnormalities when compared to DTI, thereby highlighting the ratio's sensitivity to subtle differences in cerebral WM structural integrity using only conventional MRI sequences.

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