Lab of Dr. Ali Bazarbachi

Research Interests

  • Targeted therapy of leukemia and lymphoma (in vitro and preclinical animal models) with special emphasis on HTLV-I associated adult T cell leukemia/lymphoma and NPM1 mutated acute myeloid leukemia
  • Molecular mechanisms of NF-B activation in leukemia and lymphoma with special emphasis on oncoprotein post-translational modifications
  • Cancer stem cells and leukemia initiating cells
  • Bone marrow transplantation

Selected Publications

Reducing the global burden of HTLV-1 infection: An agenda for research and action.
Willems L, Hasegawa H, Accolla R, Bangham C, Bazarbachi A, Bertazzoni U, Carneiro-Proietti AB, Cheng H, Chieco-Bianchi L, Ciminale V, Coelho-Dos-Reis J, Esparza J, Gallo RC, Gessain A, Gotuzzo E, Hall W, Harford J, Hermine O, Jacobson S, Macchi B, Macpherson C, Mahieux R, Matsuoka M, Murphy E, Peloponese JM, Simon V, Tagaya Y, Taylor GP, Watanabe T, Yamano Y.
Antiviral Res. 2017; 137:41-48.

Veno-occlusive disease/sinusoidal obstruction syndrome after haematopoietic stem cell transplantation: Middle East/North Africa regional consensus on prevention, diagnosis and management.
Al Jefri AH, Abujazar H, Al-Ahmari A, Al Rawas A, Al Zahrani Z, Alhejazi A, Bekadja MA, Ibrahim A, Lahoucine M, Ousia S, Bazarbachi A.
Bone Marrow Transplant. 2017; 52(4):588-591.

Hyper-CVAD Compared With BFM-like Chemotherapy for the Treatment of Adult Acute Lymphoblastic Leukemia. A Retrospective Single-Center Analysis.
El-Cheikh J, El Dika I, Massoud R, Charafeddine M, Mahfouz R, Kharfan-Dabaja MA,Bazarbachi A.
Clin Lymphoma Myeloma Leuk. 2017; 17(3):179-185.

No significant HTLV seroprevalence in German people who inject drugs.
Hohn O, Norley S, Kücherer C, Bazarbachi A., El Hajj H, Marcus U, Zimmermann R, Bannert N.
PLoS One. 2017; 12(8):e0183496.

Striving to cure adult T-cell leukaemia/lymphoma: a role for allogeneic stem cell transplant?
Phillips EH, Hodson A, Hermine O, Bazarbachi A., Cwynarski K.
Bone Marrow Transplant. 2016; 51(12):1549-1555.

Ongoing Research Projects

  • Eradication of leukemia initiating cells in adult T-cell leukemia/lymphoma
  • The Role of genetic Polymorphisms of Drug Metabolizing Enzymes and Transporters in the Interaction between Voriconazole & Cyclosporine in Patients undergoing Allogeneic Stem cell Transplantation: A Pilot Study
  • Investigating the Pathophysiology of Adult T-Cell Leukaemia/Lymphoma and the Role of Post Translational Modification of the Tax Oncoprotein Following Arsenic/Interferon Treatment
  • Pathophysiology of HTLV-I associated adult T-cell leukemia/lymphoma and mechanism of action of targeted therapies.
  • ​APL Model for Oncogene-Targeted Leukemia Cure