Lab of Dr. Wassim Abou Kheir

​ ​​​​​​​​​​​​​​​​​​​​​​​​​​​​​Link to Dr. Wassim Abou Kheir​ ​FMIS Profile​ ​

​​​​​Research Interests

Isolation, characterization, and targeting of cancer stem cells from solid tumors; The role of cancer stem cells in the initiation, progression and development of castration-resistant prostate cancer; Developing novel human prostate cancer cell lines spanning the spectrum of the disease; modulation of Neurogenesis and neural stem cells; generating patient-derived organoids from different solid tumors.

Establishing clinically-relevant models of prostate cancer using mouse cells, Prostate cancer and diabetes, The role of developmental pathways (SHH) in prostate cancer, Targeting prostate cancer stem cells using old and novel drugs and compounds, Embryonic stem cells (ESC) and induced pluripotent stem cells (iPSC) differentiation, Stem cells and neurogenesis.

Selected Publications

Characterizing the contribution of stem/progenitor cells to tumorigenesis in Pten-/-P53-/- prostate cancer model.
Abou-Kheir WG, Hynes P, Martin P, Pierce R, Kelly K;
Stem Cells. 2010; 28(12):2129-40

Berberis libanotica Ehrenb Extract Shows Anti-Neoplastic Effects on Prostate Cancer Stem/Progenitor Cells.
El-Merahbi R, Liu YN, Eid A, Daoud G, Hosry L, Monzer A, Mouhieddine TH, Hamade A, Najjar F, Abou-Kheir W.
PLoS One. 2014; 9(11):e112453.

Thalamic Stimulation in Awake Rats Induces Neurogenesis in the Hippocampal Formation.
Chamaa F, Sweidan W, Nahas Z, Saade N, Abou-Kheir W.
Brain Stimulation. 2016; 9(1):101-8.

Metformin and Ara-a Effectively Suppress Brain Cancer by Targeting Cancer Stem/Progenitor Cells.
Mouhieddine TH, Nokkari A, Itani MM, Chamaa F, Bahmad H, Monzer A, El-Merahbi R, Daoud G, Eid A, Kobeissy FH, Abou-Kheir W.
Front Neurosci. 2015; 9:442.

Primary versus castration resistant prostate cancer: modeling through novel murine prostate cancer cell lines.
Daoud G, Monzer A, Bahmad H, Chamaa F, Hamdar L, Mouhieddine TH, Shayya S, Eid A, Kobeissy F, Liu YN, Abou-Kheir W.
Oncotarget. 2016; 7(20):28961-75.

Awards

  • The Arab-American frontiers fellowship award
  • The Daniel Turnberg Travel Fellowship Award
  • The Farouk Jabre Grant Award
  • The International Society for Stem Cell Research Travel Award (ISSCR)
  • ​​​Program Projects in Biomedical Research Award (AUB-FM)​