Lab fo Dr. Ayad Jaffa

Main Links
- About AUB
  About AUB
  
  Founded in 1866, the American University of Beirut is a teaching-centered research university based on the American liberal arts model of higher education. AUB has over 8,000 students and 800 faculty members. The University encourages freedom of thought and expression and seeks to graduate men and women committed to creative and critical thinking, lifelong learning, personal integrity, civic responsibility, and leadership.
- Academics
  Academics
  
  AUB is accredited in the US by the Middle States Commission on Higher Education and includes six faculties: Arts and Sciences, Medicine, Engineering and Architecture, Agricultural and Food Sciences, Health Sciences, and Business. AUB offers more than 130 programs leading to bachelor's, master's, MD, and PhD degrees. The main language of instruction is English.
- Admissions
  Admissions
  
  Learn more about how you can join the American University of Beirut. AUB seeks applicants with a proven record of academic excellence, intellectual vitality, and civic responsibility. In accordance with its founding mission and its equal opportunity policy, the University admits students regardless of race, color, religion, gender, age, disability, or nationality.
- Research
  Research
  
  The vibrant and dynamic research environment at AUB enhances the educational experience for all and serves the wider communities—local and global—by advancing knowledge in a wide range of disciplines.
- Outreach
  Outreach
  
  Recognizing and honoring our responsibility for others has been an integral part of AUB’s mission since the earliest days. Today, AUB is at the forefront of addressing the most pressing concerns of this country, this region, and its people.
- Boldly Campaign
  BOLDLY Campaign
  
  To ensure the University can continue to inspire current and future generations of smart and able students who can rise to this challenge, we are embarking on a transformative capital campaign, BOLDLY AUB: The Campaign to Lead, Innovate, and Serve.
AUB Community
- A - Z
- Find People
- Libraries
- Alumni
Public
- Telehealth
- AUBMC
- Give
Useful Tools
- E-learning
- AUBSIS
- Webmail
- Title IX Online Training

Lab fo Dr. Ayad Jaffa

HomeCurrently selected
About Us
- Chairperson’s Welcome Message
- Mission and Vision
Directory
- Faculty Members
- Administrative Staff
Educational Programs
Research Activities
Contact Us
Recent

Link to Dr.Jaffa's FMIS Profile

Research Area

Research program in my laboratory is translational in nature and is focused on elucidating the genetic, molecular and cellular determinants that foster the development of diabetic vascular complications. Over the years my laboratory has contributed significantly too much of our understanding of the involvement of the kallikrein-kinin system (KKS) in the pathogenesis of diabetic renal and vascular disease, uncovering novel mechanisms of receptor activation, signal transmission and receptor cross talk and heterodimerization.

Research Focus

Biomarkers of diabetic complications (Diabetic Nephropathy, Atherosclerosis and Cardiovascular Disease).
Growth factors and signal transduction mechanisms
Cross-talk between G-protein coupled receptors and tyrosine kinase receptors
G-Protein coupled receptor heterodimerization and down-stream signals
Proteome signature of diabetic complications

Selected Publications

Plasma connective tissue growth factor levels predict myocardial infarction in the Veterans Affairs Diabetes Trial (VADT) cohort
Kelly J Hunt, Miran A Jaffa, Sara M Garrett, Deirdre K Luttrell, Kenneth E Lipson, Maria F Lopes-Virella, Louis M Luttrell, Ayad A Jaffa
Diabetes Care 41:840-846, 2018.

Proteome profiling in the aorta and kidney of type 1 diabetic rats.
Al Hariri M, Elmedawar M, Zhu R, Jaffa MA, Zhao J, Mirzaei P, Ahmed A, Kobeissy F, Ziyadeh FN, Mechref Y, Jaffa AA
PLoS One. Nov 9;12:e0187752. 2017

Multivariate Generalized Linear Mixed Models With Random Intercepts To Analyze Cardiovascular Risk Markers in Type-1 Diabetic Patients.
Jaffa MA, Gebregziabher M, Luttrell DK, Luttrell LM, Jaffa AA
J Appl Stat. 43(8):1447-1464, 2016

Plasma Prekallikrein is Associated with Carotid Intima-Media Thickness in Type 1 Diabetes.
Jaffa MA, Luttrell D, Schmaier AH, Klein RL, Lopes-Virella M, Luttrell LM, Jaffa AA
Diabetes, 65(2):498-502, 2016

The arrestin-selective antagonist AT1 receptor agonist Sar-Ile4-Ile8-AngII negatively regulates B2-receptor signaling via AT1-B2 receptor heterodimers.
Wilson PC, Lee MH, Appleton KM, El-Shewy HM, Morinelli TA, Peterson YK, Luttrell LM, Jaffa AA
J Biol Chem 288 (26):18872-84 2013

Contact Us

For various questions, please try contacting us via social media first!
read more

Privacy Statement

We take data privacy seriously and adhere to all applicable data privacy laws and regulations.
read more

Copyright and Disclaimer

Written permission is needed to copy or disseminate all or part of the materials on the AUB website.
read more

Title IX, Non-Discrimination, and Anti-Discriminatory Harassment

AUB is committed to providing a safe, respectful, and inclusive environment to all members of its community.
read more

American University of Beirut