American University of Beirut

 Lab of Dr. Nadine Darwiche

​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​Link to Dr.Darwiche​'s​ FMIS Profile

​​​Research Area

Mechanisms of cancer prevention and targeted cancer therapy by retinoids Anticancer drug development from natural resources

Research Projects

  • Mechanism of action and efficacy of the sesquiterpene lactone HNA-2 in acute myeloid leukemia and colorectal cancer
  • Cross-talk between bradykinin and retinoic acid receptors signaling in colorectal cancer: Novel therapeutic opportunities
  • Preclinical efficacy of the synthetic retinoid ST1926 and novel derivative in colorectal cancer
  • Colorectal cancer cell metabolism: Pentose phosphate pathway and effects of retinoids
  • Targeted therapy of adult T cell leukemia/lymphoma and acute myeloid leukemia by the novel synthetic retinoid ST1926 and derivatives
  • Mechanism of action of anticancer inhibitors of DNA polymerase

Selected Publications

New insights into the mechanism of action of the atypical retinoid ST1926 in colorectal cancer: DNA damage and DNA polymerase α
Abdel-Samad, R., Aouad, P., Gali-Muhtasib, H., Sweidan, Z., Hmadi, R., Kadara, H., D’Andrea, E.L., Fucci, A., Pisano, C. and *Darwiche, N.
American Journal of Cancer Research Jan. 1; 8(1):39-55, 2018

The anti-tumor activity of the synthetic retinoid ST1926 on primary effusion lymphoma in vitro and in vivo models
Karam, L., Housheimi, B., Abdel-Samad, R., Jaafar, M., Halloum, I., Pisano, C., Neipel, F., *Darwiche, N. and Abou Merhi, R.
Oncology Reports 39(2): 721-730, 2018.

Antitumor effect of the atypical retinoid ST1926 in acute myeloid leukemia and nanoparticle formulation prolongs lifespan and reduces tumor burden of xenograft mice.
El-Houjeiri, L., Saad, W., Hayar, B., Aouad, P., Tawil, N., Abdel-Samad, R., Hleihel, R., Hamie, M., Mancinelli, A., Pisano, C., El Hajj, H. and *Darwiche, N.
Molecular Cancer Therapeutics. 16(10):2047-2057, 2017

Anti-tumor activities of the synthetic retinoid ST1926 in two-dimensional and three-dimensional human breast cancer models.
Aouad, P., Saikali, M., Abdel-Samad, R., Fostok, S., El-Houjeiri, L., Pisano, C., Talhouk, R. and *Darwiche, N.
Anticancer Drugs 28(7):757-770, 2017.

The synthetic retinoid ST1926 as a novel therapeutic agent in rhabdomyosarcoma.
Basma, H., Ghayad, S.E., Rammal. G., Mancinelli, A., Harajly, M., Ghamloush, F., Dweik, L., El-Eit, R., Zalzali, H., Rabeh, W., Pisano, C., Darwiche, N. and Saab, R.
International Journal of Cancer 138(6):1528-37, 2016.​

Research Grants

​​​Tit​l​e: Mechanism of Action and Efficacy of the Anticancer Drug HNA-2 in Acute Myeloid Leukemia and Colorectal Cancer
Role: Principal Investigator
Source: Hikma Pharmaceuticals Company, Amman, Jordan
Year: 2018 - 2019 ​
​​​​Tit​l​e: Cross-talk between Bradykinin and Retinoic Acid Receptors Signaling in Colorectal Cancer: Novel Therapeutic Opportunities
Role: Principal Investigator
Source:Medical Practice Plan of AUB and University Research Board of AUB
Year: 2016-2018 
​​​​​Tit​l​e: Preclinical Efficacy of the Synthetic Retinoid ST1926 and Novel Derivative in Colorectal Cancer  
Role: Principal Investigator
Source: Lebanese National Council for Scientific Research, Beirut-Lebanon 
Year: 2017-2019
Tit​l​e:Retinoids and Prostate Cancer: Deciphering the Mechanisms of Action and Evaluating the Anti-neoplastic Activities of the Synthetic Retinoid ST1926 on Prostate Cancer​
Role: Co-Investigator​
Source: Medical Practice Plan and University Research Board of AUB 
Year: 2015-2018 ​


Future Leader in Cancer Research from low- and middle-income countries
​Biomedical Research Day, Best Presentation  
​Biomedical Research Day,  ​Seventh annual- Cancer category
​Biomedical Research Day, ​​annual- Biomedical Engineering category
​Biomedical Research Day, ​​Fourth annual-Cancer category
Biomedical Research Day, First annual- Oral presentation​
Lindbergh Foundation Award Recipient- For Balancing Technology and the Environment
Teaching Excellence Award- American University of Beirut/Lebanon ​

Contact Us

For various questions, please try contacting us via social media first!
read more

Privacy Statement

We take data privacy seriously and adhere to all applicable data privacy laws and regulations.
read more

Copyright and Disclaimer

Written permission is needed to copy or disseminate all or part of the materials on the AUB website.
read more

Title IX, Non-Discrimination, and Anti-Discriminatory Harassment

AUB is committed to providing a safe, respectful, and inclusive environment to all members of its community.
read more