Lab of Dr. Margret Shirinian

​​​​​​​​​​​​​​​​​​​​​​​​​​​Link to Dr.Shirinian's​ FMIS Profile

​​​​​​​​​​​​​​​​​​​​​Rese​arch Area

Genetics (Drosophila melanogaster), Epigenetics, Cancer, Molecular Biology

​​​​​​​​​​​​​​​​​Research P​rojects

  • Unraveling TET function in Drosophila melanogaster
  • In vitro characterization of oncogenic potential of TET
  • Understand the effects of expressing fusion onco-proteins in the in vivo Drosophila melanogaster model system
  • Identify immune pathways modulated by oncogene expression both innate and humoral immune responses

​​​​​​​​​​​​​​​​​Selected Publications

A Transgenic Drosophila Melanogaster Model To Study Human T-Lymphotropic Virus Oncoprotein Tax-1-Driven Transformation In Vivo.
Shirinian M, Kambris Z, Hamadeh L, Grabbe C, Journo C, Mahieux R, Bazarbachi A
Journal Of Virology. 2015, vol.89, no.15, pp-8092-5​

Non-Random Aneuploidy Specifies Subgroups Of Pilocytic Astrocytoma And Correlates With Older Age.
Fontebasso AM, Shirinian M, Khuong-Quang DA, Bechet D, Gayden T, Kool M, De Jay N, Jacob K, Gerges N, Hutter B, Åeker-Cin H, Witt H, Montpetit A, Brunet S, Lepage P, Bourret G, Klekner A, Bognár L, Hauser P, Garami M, Farmer JP, Montes JL, Atkinson J, Lambert S, Kwan T, Korshunov A, Tabori U, Collins VP, Albrecht S, Faury D, Pfister SM, Paulus W, Hasselblatt M, Jones DT, Jabado N
Oncotarget. 2015, vol.6, no.31, pp-31844-56​

Tax-1 And Tax-2 Similarities And Differences: Focus On Post-Translational Modifications And Nf-κb Activation.​
Shirinian M, Kfoury Y, Dassouki Z, El-Hajj H, Bazarbachi A
Frontiers In Microbiology. 2013, vol.4, pp-231

Genetic Aberrations Leading To Mapk Pathway Activation Mediate Oncogene-Induced Senescence In Sporadic Pilocytic Astrocytomas.​
Jacob K, Quang-Khuong DA, Jones DT, Witt H, Lambert S, Albrecht S, Witt O, Vezina C, Shirinian M, Faury D, Garami M, Hauser P, Klekner A, Bognar L, Farmer JP, Montes JL, Atkinson J, Hawkins C, Korshunov A, Collins VP, Pfister SM, Tabori U, Jabado N
Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research. 2011, vol.17, no.14, pp-4650-60

Braf-Kiaa1549 Fusion Predicts Better Clinical Outcome In Pediatric Low-Grade Astrocytoma.​
Hawkins C, Walker E, Mohamed N, Zhang C, Jacob K, Shirinian M, Alon N, Kahn D, Fried I, Scheinemann K, Tsangaris E, Dirks P, Tressler R, Bouffet E, Jabado N, Tabori U
Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research. 2011, vol.17, no.14, pp-4790-8​

​​​​​​​​​​​​​​​​​Research Grants​



​​​​​Tit​l​e: Optimizing targeted therapy of chronic Myeloid​​ Le​​ukemia​ 
Source: CNRS
Year: 2018 ​– 2020​

Tit​l​e
: Characterization of the molecular and physiological role of TET proteins in Glioblastoma
Source: AUBMC-Medical Practice Plan
Year: 2015 ​– 2017​
​​​​
Tit​l​e:Investigating the Pathophysiology of Adult T-cell leukemia/lymphoma and the role of Posttranslational modification of the Tax oncoprotein following Arsenic/Interferon treatment
Source: Vetneskapsradet Swedish National Grant 
Year: 2014 – 2017​​

​​​​​Tit​l​e:Drosophila melanogaster as a model system to study tumor induced immune responses in Anaplastic large cell lymphoma (ALCL)
Source:Seed AUB-FM 
Year: 2015 - 2016​ 


Awards


​​2013​  
​ TATA POSTDOCTORAL GRANT IN LEUKEMIA RESEARCH
 TATA Institute , United Kingdom
 TATA InternationalPostdoctoral award for Leukemia
​2011​ 
 Stars Foundation Award
 Montreal Childrens Hospital, Canada
 Stars Foundation Post-doctoral Award
​2010​ 
 MICRTP Award
 McGill University, Canada
 McGill Integrated Cancer Research Training Program For Post-doctoral Researchers
​2010​  
 Stars Foundation Award
 Montreal Childrens Hospital, Canada
 Stars Foundation Post-doctoral Award
​2007​
 Kempe (​​​SJCKMS) SWEDISH AWARD
 Kempe, SWEDEN
 PhD student Award
​2006​
 Wallenberg Foundation Award
 Wallenberg, Sweden
 Travel Allowance