American University of Beirut

 Lab of Dr. Margret Shirinian

​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​Link to Dr.Shirinian's​ FMIS Profile

​​​​​​​​​​​​​​​​​​​​​Rese​arch Area

Genetics (Drosophila melanogaster), Epigenetics, Cancer, Molecular Biology

​​​​​​​​​​​​​​​​​Research P​rojects

Epigenetics in development and disease 

  • Role of Drosophila dTet in brain development 
  • Role of TET proteins in development and disease 
  • Role of oncohistones in development and cancer  

       For website bigger 2.jpg      

Research Personnel Supervised ​

Name: Felice Frey
Position: Post-doctoral fello​​w ​
Phone extension: 5126​

Name: Joy Ismail
Position: PhD candidate  
Phone extension: 5126​
Name: Mirna Ghannam
Position: Research assistant
Phone extension: 5126
Name: Amani Al Outa
Position: PhD candidate​​
Phone extension: 5126
Name: Joelle Mady
Position: Masters Student
Phone extension: 5126
Name: Dana Abubaker 
Position: Masters Student
Phone extension: 5126​

​​​​​​​​​​​​​​​​​Selected Publications

Drosophila Tet is expressed in midline glia and is required for proper axonal development.
Ismail N J, Badini S, Frey, F, Abou-Kheir W, Shirinian M
Frontiers in Cellular Neuroscience. 2019

Mutated H3 Histones Drive Human Pre-Leukemic Hematopoietic Stem Cell Expansion And Promote Leukemic Aggressiveness.
 Boileau M*, Shirinian M*, Gayden T*, Harutyunyan A, Chen C, Mikael L, Duncan H,Neumann A, Arreba-Tutusaus P, De Jay N, Zeinieh M, Rossokhata K,  Zhang Y, Nikbakht H, Mouawad C, Massoud R, Frey F, Nasr R, El Cheikh J, El Sabban M, Kleinman C, Mahfouz R, Minden M, Jabado N**, Bazarbachi A**, Eppert K**. 
Nature Communications. 2019

Validation Of A Drosophila Model Of Wild Type And T315i Mutated Bcr-Abl1 In Chronic Myeloid Leukemia: An Effective Platform For Treatment Screening.
Al Outa A, Abubaker D, Bazarbachi A, El Sabban M, Shirinian M*, Nasr R*
Haematologica. 2019

Identification Of Genes Functionally Involved In The Detrimental Effects Of Mutant Histone H3.3-K27m In Drosophila Melanogaster.
Berlandi J, Chaouch A, De Jay N, Tegeder I, Thiel K, Shirinian M, Kleinman CL, Jeibmann A, Lasko P, Jabado N, Hasselblatt M
Neuro-Oncology. 2019

The Htlv-1 Oncoprotein Tax Is Modified By The Ubiquitin Related Modifier 1 (Urm1).
Hleihel R, Khoshnood B, Dacklin I, Omran H, Mouawad C, Dassouki Z, El-Sabban M, Shirinian M*, Grabbe C*, Bazarbachi A*
Retrovirology. 2018

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