Lab of Dr. Michel Massaad

​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​Link to Dr.Massaad's​ FMIS Profile

​​​​​​​​​​​​​​​​​​​​​​​​Rese​arch Area

Immunology/Primary Immunodeficiency

Research P​rojects

Functional and Genetic study of Primary Immunodeficiency Patients

Selected Publications​

A peptide derived from the Wiskott-Aldrich syndrome (WAS) protein-interacting protein (WIP) restores WAS protein level and actin cytoskeleton reorganization in lymphocytes from patients with WAS mutations that disrupt WIP binding
Massaad M.J.*,Ramesh N., Le Bras S., Giliani S., Notarangelo L., Al-Herz W., Notarangelo LD, Geha R.S.
Journal of Allergy and Clinical Immunology. Apr;127(4):998-1005.e1-2. PMID: 21376381 ​

Binding of WIP to actin is essential for T cell actin cytoskeleton integrity and tissue homing
Massaad M.J., Oyoshi MK, Kane J, Koduru S, Alcaide P, Nakamura F, Ramesh N, Luscinskas FW, Hartwig J, and Geha RS
Molecular and Cellular Biology. Dec 1;34(23):4343-54 ​

Autoimmune lymphoproliferative syndrome caused by a homozygous FasL mutation that disrupts FasL assembly
Sobh A., Crestani E., Cangemi B., Kane J., Chou J., Pai SY., Notarangelo LD., Al-Herz W., Geha R.S.*, Massaad M.J.*
Journal of Allergy and Clinical Immunology. October 9. pii: S0091-6749(15)01249-X

Chronic mucocutaneous candidiasis associated with an SH2 domain gain of function mutation that enhances STAT1 phosphorylation
Sobh A., Chou J., Schneider L., Geha R Massaad M.J.*
Journal of Allergy and Clinical Immunology. Feb 29. pii: S0091-6749(16)00131-7

Deficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity
Massaad M.J.*, Zhou J, Tsuchimoto D, Chou J, Jabara H, Janssen E, Glauzy S, Olson BG, Morbach H, Ohsumi TK, Schmitz K, Kyriacos M, Kane J, Torisu K, Nakabeppu Y, Notarangelo LD, Chouery E, Megarbane A, Kang PB, Al-Idrissi E, Aldhekri H, Meffre E, Mizui M, Tsokos GC, Manis JP, Al-Herz W, Wallace SS, Geha RS
Journal of Clinical Investigation. Nov 1;126(11):4219-4236​

Awards

​​
2014-2019
​Boston Children’s Hospital Investigatorship Award
​2014
​Best Poster Award at the European Society for Immunodeficiencies 
​2007
​Paul A. Dobuler Prize for “Excellence in Immunodeficiency Research”
​2001-2002
​McGill Faculty of Graduate Studies Scholarship
​1999-2003​​
​McGill Faculty of Medicine Sch​olarship​​
​​​1997-1998FCAR McGill Cancer Centre Scholarship ​
​1999, 2000Canderel Travel Award, McGill Cancer Centre
​​​1998McKinnell Travel Award, McGill University​
1993-1996Biology Department Scholarship
1988-1992​
Hariri Foundation Scholarship