American University of Beirut

 Lab of Dr. Nathalie Khoueiry Zgheib

​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​Link to Dr. Zgh​eib's​​ FMIS Profile

​​​​​​​​​​​​​​​​​​​​​​​​​​​​Rese​arch Area

  • Pharmacogenetics and pharmacoepigenetics of non-communicable diseases
  • Toxicology research

Research P​rojects

  • Epigenetics, pharmacoepigenetics and toxicoepigenetics of breast cancer
  • Pharmacogenetics of acute childhood leukemias
  • Pharmacogenetics of epilepsy
  • Nutrigenetics of obesity
  • Pharmacogenetics of antifungals and immunosuppressants in patients undergoing allogenic stem cell transplantation
  • Environmental exposure to endocrine disruptors and its association with diseases.
  • Epigenetic and telomerase linked mechanisms behind the carcinogenic potential of Bisphenol A and its analogues
  • The association of airborne particles and their PAH content with coronary artery disease burden
  • Online teaching of Pharmacogenetics and personalized medicine (OPPM) http://oppmprogram.com​

Selected Publications

​ Google scholar publications: https://scholar.google.com/citations?user=vMile4UAAAAJ&hl=en 
 Scopus publications:  https://www.scopus.com/authid/detail.uri?authorId=14036688800​ 

Personnel

Ms. Reem Akika, Lab Manager​
Email: ra223@aub.edu.lb

Research Grants

​Title​​
​Role
​Source
​Year

​The Role of ACE2, TMPRSS2 and OAS1 Candidate Genetic Polymorphisms in COVID-19 Infection Susceptibility and Severity

​Principal Investigator

​Scholarly Concentration Track AUBFM

​2022 - 2024​

​The Role of Candidate Pharmacogenetic Variants in Determining Valproic Acid Efficacy, Plasma Levels, and Toxicity in the Treatment of Lebanese Patients With Epilepsy

​Principal Investigator

Medical Student Research Award AUBFM

​2022 - 2024

​Online Pharmacogenomics and Personalized Medicine postgraduate program/OPPM: https://ec.europa.eu/programmes/erasmus-plus/projects/eplus-project-details/#project/617303-EPP-1-2020-1-EG-EPPKA2-CBHE-JP

​Principal Investigator

​ERASMUS Collaboration with Egypt

​2021 - 2024

​Pharmacogenetics in childhood ALL: from variants identification to clinical implementation

​Principal Investigator

​Qatar Foundation

​2021 - 2024

​Marqueurs épigénétiques du tabagisme à la chicha en comparaison avec ceux à la cigarette dans laddiction et la maladie

​co-Investigator

​Institut National du Cancer (INCA) Institut pour la Recherche en Sante Publique IRESP

​2021 - 2023

​Diana Tamari Sabbagh Scholarship Program (DTSSP) for 1 graduate student (Ibrahim Ridany)

​Principal Investigator

​DTS

​2022 - 2023

​STREAM into College

​Co-Principal Investigator

​European Union

​2021 - 2022

​Epigenetic alterations associated with acute and chronic cigarette and waterpipe smoke extract exposure in breast cancer cells

​Principal Investigator

​AUBMC-MPP

​2021 - 2022

​AHRR Hypomethylation as a biomarker of exposure to ambient air pollution and risk factor for obstructive coronary artery disease

​Principal Investigator

​AUBMC-MPP

​2021 - 2022

​Reconceptualizing medical education in the post-covid era

​Co-Principal Investigator

​CTL SOTL

​2021 - 2022

​Diana Tamari Sabbagh Scholarship Program (DTSSP) for 3 graduate students (Carole Abdel Karim, Dania Kabbani, Karna Jabotian)

​Principal Investigator

​DTS

​2021 - 2022

​DNA Methylation Aberrations Induced by Cigarette and Narjileh Smoking in Lung Carcinogenesis

​Principal Investigator

​AUBMC-MPP

​2019 - 2021

​Cardiovascular and mental health profiles in a middle-aged Lebanese community-based cohort

​co-Investigator

​AUBMC-MPP

​2019 - 2021

​Genetic and Epigenetic Alterations Induced by Cigarette and Narjileh Smoking in Bladder Cancer in Lebanon

​Principal Investigator

​WHO IARC

​2019 - 2021

​The Role of Angiotensin Converting Enzyme Insertion/Deletion Genetic Polymorphism in the Risk, Severity and Prognosis of COVID-19 infection

​Principal Investigator

​LNCSR

​2020

​Maps of Coronary Artery Disease Burden and AiR Quality Danger Spots in the Greater Beirut Area (MARQ-Beirut)
​​Co-Principal Investigator
​CNRS

​2017 - 2019
​Epidemiology and biomarkers of air pollution and burden of coronary artery disease: risks, protective factors, and implications for prevention
​Co-Principal Investigator
​URB
​2017 - 2019
​The epigenetic and telomerase linked mechanisms behind the carcinogenic potential of Bisphenol A and its analogues (Bisphenol F and Bisphenol S) in breast cell lines
Principal Investigator
​AUBMC-MPP
2012019
​Podocyturia mRNAs: earlier and superior predictors of cardiovascular outcomes in diabetic and non diabetic patients
​Co-Investigator
AUBMC-MPP
2016 2019
​PhD Award Program with CNRS and Zainab Awada: Influence of bisphenol A on breast cancer development and metastasis via estrogen receptor alpha epigenetics and telomere linked mechanisms
Principal Investigator
CNRS
​ 2015 - 2018
​Repository of cardiovascular diseases at AUBMC
​​​​Co-Principal Investigator
​AUBMC VMP
​2014
The role of peripheral WBCs ABCB1 promoter methylation with docetaxel related neutropenia in breast cancer patients: a toxicoepigenetic proposal
Principal Investigator
​AUBMC-MPP
​2016 - 2017
​The Effect of Vitamin D on Th17 cells’ VDR Promoter Methylation and Expression
​​​​​Co-Principal​ Investigator
​AUBMC-MPP
​​2016 - 2017
​The Role of Genetic Polymorphisms of Drug Metabolizing Enzymes and Transporters in the Interaction between Voriconazole and Cyclosporine in Patients Undergoing Allogenic Stem Cell Transplantation: A Pilot study
​Co-Investigator
​PFIZER GULF
​2016 - 2017


​​Awards​


​2020
​​Shoman Arab Researchers Award in Pharmacogenetics 
2013​

TBLC consultant
​2011
​Teaching excellence Award
​2004 
Merck Sharp & Dohme Doctoral scholarship in clinical pharmacology
​2003
Spark Entrepreneurship Network: Business plans: Geriatrics Home Care & Obstetrics Facility
1998
Alpha Omega Alpha Honor Medical Society





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