At AUBMC the office of clinical and translational research aims to facilitate and support investigators involved in clinical and translational research. Our aim is to change the culture of research to allow investigators to easily collaborate and benefit from the existing and developing infrastructure. NIH defines human clinical research as research with human subjects that is:
- Patient-oriented research. Research conducted with human subjects (or on material of human origin such as tissues, specimens and cognitive phenomena) for which an investigator (or colleague) directly interacts with human subjects. Excluded from this definition are in vitro studies that utilize human tissues that cannot be linked to a living individual. Patient-oriented research includes:
- mechanisms of human disease
- therapeutic interventions
- clinical trials
- development of new technologies
- Epidemiologic and behavioral studies
- Outcomes research and health services research
Source: NIH PHS 398 Instructions on Human Subjects Research
Translational Research
Translational research includes:
- The process of making discoveries in the research laboratory or in preclinical studies that will have an impact on human health and may lead to the development of studies in humans
- The process of applying discoveries generated during research in the laboratory, and in preclinical studies, to the development of trials and studies in humans
- Research aimed at enhancing the adoption of best practices in the community. Cost-effectiveness of prevention and treatment strategies is also an important part of translational science.
Translational research includes two areas of translation. One is the process of applying discoveries generated during research in the laboratory, and in preclinical studies, to the development of trials and studies in humans. The second area of translation concerns research aimed at enhancing the adoption of best practices in the community. Cost-effectiveness of prevention and treatment strategies is also an important part of translational science.
Source: Based on Institutional Clinical and Translational Science Award (U54)
RFA-RM-07-007 CTSA RFA Khoury M et al. Genet Med 2007:9(10):665–674