American Univesity of Beirut

Anti-inflammatory bio-activities in water extract of Centaurea ainetensis

​​Talhouk, R.S., El-Jouni, W., Kogan, J. Baalbaki, R., Mohtaseb, H., Talhouk, S., and Barbour, E.K.  Anti-inflammatory bio-activities in water extract of Centaurea ainetensis.  Journal of Medicinal Plants Research 2008 2:024-033.

Abstract
 
Of a selected 29 plants endemic to Lebanon and claimed to have anti-inflammatory effects, according to Lebanese folk literature, Centaurea ainetensis was chosen to further characterize its claimed anti-inflammatory activity using in-vitro and in-vivo assays. Water extract from C. ainetensis, at noncytotoxic concentrations, inhibited in a dose dependant manner interleukin-6 (IL-6) and gelatinases A and B produced by endotoxin (ET)-treated CID-9 cells grown in conditions that favor differentiation, on EHS-drip, at 9, 24 and 48 h post ET treatment. The inhibition was detected in doses as low as 3% (of a 1:8 decoction) and reached maximal levels of inhibition at 8% similar to control non ET-treated cells. C. ainetensis extract at these concentrations did not affect CID-9 cell’s expression of   casein, a milk protein expressed by functionally differentiated mammary cells in culture. In vivo studies showed that C. ainetensis extract reversed ET-induced paw edema and thermal hyperalgesia in rats as demonstrated by hot plate and heat hyperalgesia pain tests.

Contact Us

For various questions, please try contacting us via social media first!
read more

Privacy Statement

We take data privacy seriously and adhere to all applicable data privacy laws and regulations.
read more

Copyright and Disclaimer

Written permission is needed to copy or disseminate all or part of the materials on the AUB website.
read more

Title IX, Non-Discrimination, and Anti-Discriminatory Harassment

AUB is committed to providing a safe, respectful, and inclusive environment to all members of its community.
read more