American University of Beirut

​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​Clinical Trials

• Vitamin D Supplementation at Low (600 IU/day) or Higher Dose (3,750 IU/day) Does Not Improve Insulin Resistance Markers at One Year: A Randomized Controlled Trial.​
  Safwan N, Mantzoros CS, Rahme M, Baddoura R, Halaby G, El-Hajj Fuleihan G.
  Metabolism Open 2025; https://doi.org/10.1016/j.metop.2025.100357
  
• Blood Pressure Decreases in Overweight Elderly Individuals on Vitamin D: A Randomized Trial.​ Rahme M, Al-Shaar L, Tamim H, El-Hajj Fuleihan G. Journal of the Endocrine Society 2024; 8(12). (Chosen for the Endocrine Society Thematic Issue on Article Highlights of 2024​).
  
• Effect of High dose Vitamin D Supplementation on Indices of Sarcopenia and Obesity Assessed by DXA Among Older Adults: A  Randomized Controlled Trial.​
  Jabbour J, Rahme M, Mahfoud Z, El Hajj Fuleihan G. Endocrine 2022; 76:162–171.​
• Vitamin D3 Dose Requirement that Raises 25-Hydroxyvitamin D to Desirable Level in Overweight and Obese Elderly.​
  Bacha D, Rahme M, Al-Shaar L, Baddoura, Georges H, Singh R, Mahfoud Z, Habib R, Arabi A. JCEM 2021; 106(9):e3644-e3654.​
• Total, bioavailable, and free 25(OH)D relationship with indices of bone health in elderly: a randomized controlled trial.​
  El Sabeh M, Ghanem P, Al-Shaar L, Rahme M, Baddoura R, Halaby G, Singh RJ, Vanderschueren D, Bouillon R, El-Hajj Fuleihan G. JCEM 2021; 106(2):e990-e1001.
  
• Delta-like 1 (DLK1) is a possible mediator of vitamin D effects on bone and energy metabolism.
  Bassatne A, Jafari A, Kassem M, Mantzoros C, Rahme M, El-Hajj Fuleihan G. Bone 2020; 138:115510.
  
• Impact of calcium and two doses of vitamin D on bone metabolism in the elderly: a randomized controlled trial.​​
  Rahme M, Sharara SL, Baddoura R, Habib RH, Halaby G, Arabi A, Singh RJ, Kassem M, Mahfoud Z, Hoteit M, Daher RT, Bassil D, El Ferkh K, El-Hajj Fuleihan G. JBMR 2017; 32.(7):1486-1495.
• Effect of vitamin D replacement on indices of insulin resistance in overweight elderly individuals: a randomized controlled trial.​​
  El-Hajj Fuleihan G, Baddoura R, Habib R, Halaby G, Arabi A, Rahme M, Singh R, Kassem M, Mahfoud Z, Hoteit M, Daher R, Kassir MF. Am J Clin Nutr 2016; 104(2):315-323.
• Persistent Effect of Vitamin D on Bone and Lean Mass Post-Intervention.
  Ghazal N, Al-Shaar L, Maalouf J, Nabulsi M, Arabi A, Choucair M, Tamim H, Mahfoud Z, El-Hajj Fuleihan G. JBMR 2016; 31(7):1473-80.
  
• Vitamin D3 dose requirement to raise 25-hydroxyvitamin D to desirable levels in adolescents: Results from a randomized controlled trial.
  Al-Shaar L, Mneimneh R, Nabulsi M, Maalouf J, El-Hajj Fuleihan G. JBMR 2014; 29(4):944-951.
• Effect of vitamin D replacement on hip structural geometry in adolescents: A randomized controlled trial.​
  Al-Shaar L, Nabulsi M, Maalouf J, El-Rassi R, Vieth R, Beck T, El-Hajj Fuleihan G. Bone 2013; 56:296-303.
• Gender differences in the heritability of musculoskeletal and body composition parameters in mother-daughter and mother-son pairs.​
  Nabulsi M, Mahfoud Z, El-Rassi R, Al-Shaar L, Maalouf J, El-Hajj Fuleihan G. Journal of Clinical Densitometry 2013; 16(2):223-30.
• A randomized single-blind trial of standard diet versus fiber-free diet with polyethylene glycol electrolyte solution for colonoscopy preparation.
  Soweid AM, Kobeissy AA, Jamali FR, El-Tarchichi M, Skoury A, Abdul-Baki H, El-Zahabi L, El-Sayyed A, Barada KA, Sharara AI, Mourad F, Arabi A. Endoscopy 2010; 42(8):633-8.
• Short term and long term safety of vitamin D3 supplementation in school children.​​
  Maalouf J, Nabulsi M, Vieth R, Kimball S, El-Rassi R, Mahfoud Z and El-Hajj Fuleihan G. J Clin Endocrinol Metab 2008; 93(7):2693-2701.
• Impact of maternal ‎veiling during pregnancy and socioeconomic status on offspring’s musculoskeletal health.
  Nabulsi M, Mahfoud Z, Maalouf J, Arabi A, El-Hajj Fuleihan G. Osteoporos Int 2008; 19(3):295-302.
• Two randomized vitamin D trials in ambulatory patients on anticonvulsants: Impact on bone.​​
  Mikati M, Dib L, Sawaya R, Yamout B, El-Hajj Fuleihan G. Neurology 2006; 11:2005-2014.
• Effect of vitamin D replacement on musculoskeletal parameters in healthy school children: a randomized controlled trial.​​
  El-Hajj Fuleihan G, Nabulsi M, Tamim, Maalouf J, Salamoun M, Khalifeh H, Shoucair M, Arabi A, Vieth R. J Clin Endocrinol Metab 2006; 91:405-41.
• Pamidronate in the prevention of chemotherapy-induced bone loss in premenopausal women with breast cancer: a randomized controlled trial.​
  El-Hajj Fuleihan G, Salamoun M, Abou Mourad Y, Chehal A, Salem Z, Mahfoud Z, Shamseddine A. J Clin Endocrinol Metab 2005; 90:3209-3214.
  
• Effect of antiepileptic drugs on bone density in ambulatory patients.
  Farhat G, Yamout B, Mikati MA, Demirjian S, Sawaya R, El-Hajj Fuleihan G. Neurology 2002; 58:1348-1353.
• Hormone replacement therapy.​
  El-Hajj Fuleihan G. Ed A. Wayne Meikle. NEJM 2000; 342:297-298.
• Alendronate in early postmenopausal women: effects on bone mass during long term treatment and after withdrawal.
  Ravn P, Weiss SR, Rodriguez-Portales JA, McClung MR, Wasnich RD, Gilchrist NL, Sambrook P, Fogelman I, Krupa D, Yates JA, Daifotis A, El-Hajj Fuleihan G. J Clin Endocrinol Metab 2000; 85:1492-97.
• Alendronate prevents postmenopaus​al osteoporosis.​
  McClung M, Clemmesen B, Daifotis A, Gilchrist NL, Eisman J Weinstein RS, El-Hajj Fuleihan G, Reda C, Yates AJ, Ravn P. alendronate osteoporosis prevention study g​​roup. Ann Int Med 1998; 128:253-26.
• Effect of sequential and daily continuous hormone replacement therapy on indices of mineral metabolism.​​
  El-Hajj Fuleihan G, Brown EM, Curtis K, Berger M, Berger B, Gleason R, LeBoff MS. Arch Int Med 1992; 152:1904-1909.
  
  

Vitamin D/​PTH​/Obesity

• The effect of metformin on weight and metabolic parameters in patients with obesity: A systematic review and meta-analysis of randomized controlled trials.
  Zarzour F, Haber R, Saadeh N, Basha D, Jebbawi L, Ghezzawi M, Chakhtoura M, Mantzoros C. Diabetes Obes Metab 2024; 26(5):1850-1867.
  
• Mortality risk in patients with obesity and COVID-19 infection: A Systematic Review and Meta-Analysis.​
  Haber R, Ghezzawi M, Puzanian H, Haber M, Saad S, Ghandour Y, El Bachour J, Yazbeck A, Hassanieh G, Mehdi C, Ismail D, Abi-Kharma, E, El-Zein O, Khamis A, Chakhtoura M, Mantzoros CS. Metabolism 2024; 13:155812.
  
• ​​Vitamin D supplementation for improving bon​e density in vitamin D-deficient children and adolescents: systematic review and individual participant data meta-analysis of randomised controlled trials.
  Wu F, El-Hajj Fuleihan G, Cai G, Lamberg-Allardt C, Viljakainen HT, Rahme M, Gronborg IM, Andersen R, Khadilkar A, Zulf MM, Molgaard C, Larnkjær A, Zhu K, Riley RD, Winzenberg T.​ Am J Clin Nutr 2023; 118(3):498-506.​​
• A systematic review supporting the Endocrine Society Guideline on the treatment of hypercalcemia of malignancy.
  Seisa M, Nayfeh T, Hasan B, Firwana M, Saadi S, Mushannen A, Shah S, Rajjoub N, Farah M, Prokop L, Wang Z, El-Hajj Fuleihan G, Drake M, Murad H. JCEM 2023;108(3):585-591.​
  
• Pharmacotherapy of obesity: an update on the available medications and drugs under investigation.
  Chakhtoura M, Haber R, Ghezzawi M, Rhayem C, Tcheroyan R, Mantzoros CS.​ eClinicalMedicine 2023; 58:101882.
  
• Advances in physiology, design and development of novel medications changing the landscape of obesity pharmacotherapy.
  Chakhtoura M, Mantzoros C. Metabolism 2023:142:155531.
  
• Recent research advances in Metabolism, Clinical and Experimental.
  Boutari C, Kokkorakis M, Stefanakis K, Valenzuela-Vallejo L, Axarloglou E, Volčanšek S, Chakhtoura M, Mantzoros CS. Metabolism 2023; 149:155722.
  
• Vitamin D status and supplementation before and after Bariatric Surgery: Recommendations based on a systematic review and meta-analysis.​
  Giustin A, di Filippo L, Facciorusso A, Adler RA, Binkley N, Bollerslev J, Bouillon R, Casanueva FF, Cavestro GM, Chakhtoura M, Conte C, Donini LM, Ebeling PR, Fassio A, Frara S, Gagnon C, Latella G, Marcocci C, Mechanick JI, Minisola S, Rizzoli R, Santini F, Shaker JL, Sempos C, Ulivieri FM, Virtanen JK, Napoli N, Schafer AL, Bilezikian JP. Rev Endocr Metab Disord 2023; 24(6):1011-1029.
  
• ​​Patient and Physician Decisional Factors Regarding Hypercalcemia of Malignancy Treatment: A Novel Mixed-Methods Study.​​
  Bassatne A, Murad M, Piggott T, Drake M, Rahme M, El-Hajj Fuleihan G. JCEM 2022; 108(3):563-584.
• Long term weight loss diets and obesity indices: Results of a Network Meta-Analysis.
  Jabbour J, Rihawi Y, Khamis AM, Ghamlouche L, Tabban B, Safadi G, Hammad N, Hadla R, Zeidan M, Andari D, Azar R, Nasser N, Chakhtoura M. Front Nutr 2022; 9:821096.
  
• The Association of Increased Intra-abdominal Visceral Adipose Tissue with All-Cause Mortality: A Systematic Review and Meta-analysis.
  Saad R, Ghezzawi M, Horanieh R, Khamis A, Saunders KH, Batsis JA, Chakhtoura M. 
  ​Front Endocrinol 2022; 13:922931.
  
• Fracture Risk Following Bariatric Surgery: A Systematic Review and Meta-analysis.
  Saad R, Habli D, Ghezzawi M, Alami R, Chakhtoura M. Osteoporos Int 2022; 33(3):511-526.
  
• Vitamin D Supplementation and Fractures in Adults: A Systematic Umbrella Review of Meta-Analyses of Controlled Trials.​
  Chakhtoura M, Bacha D, Gharios C, Ajjour S, Assaad M, Jabbour Y, Kahale F, Bassatne A, Antoun S, Akl EA, Bouillon R, Lips P, Ebeling P, El-Hajj Fuleihan G. JCEM 2022; 107(3):882-898. Cited among top 5 % in JCEM 2023.​
• The link between COVID-19 and VItamin D (VIVID): A systematic review and meta-analysis.​
  Bassatne A, Basbous M, Chakhtoura M, El Zein O, Rahme M, El-Hajj Fuleihan G. Metabolism 2021; 119:​154753.​​
• Minimally invasive parathyroidectomy guided by intraoperative parathyroid hormone monitoring (IOPTH) and preoperative imaging versus bilateral neck exploration for primary hyperparathyroidism in adults.​  
  Ahmadieh H, Kreidieh O, Akl EA, El-Hajj Fuleihan G. Cochrane Database of Sys Rev 2020; 10(10):cd010787.
• Impact of vitamin D supplementation on falls and fractures – a critical appraisal of the quality of the evidence and an overview of the available guidelines.
  Chakhtoura M, Rahme M, Chamoun N, El-Hajj Fuleihan G. Bone 2020; 131:115112.           
• Time trends and predictors of hypovitaminosis D across the life course: 2009–2016.​
  Saad R, Akiki V, Rahme M, Ajjour S, Assad M, El-Hajj Fuleihan G. Metabolism Clinical and Experimental 2020;105:154138.    
• Rate of drop in serum calcium as a predictor of hypocalcemic symptoms post total thyroidectomy.
  Saad R, Boueiz N, Akiki V, El-Hajj Fuleihan G. Osteoporos Int 2019; 30(12):2495-2504.
• ​Limitations of platform assays to measure serum 25OHD level impact on guidelines and practice decision making.​​
  Rahme M, Al Shaar L, Singh R, Baddoura R, Halaby G, Arabi A, Habib R, Daher R, Bassil D, El-Ferkh K, Hoteit M, El-Hajj Fuleihan G. Metabolism 2018; 89:1-7.​
• Vitamin D in the middle east and north africa.​
  Chakhtoura M, Rahme M, Chamoun N, El-Hajj Fuleihan G. Bone Reports 2018;8:135-146.
• Vitamin D metabolism in bariatric surgery.​
  Chakhtoura M, Rahme M, El-Hajj Fuleihan G. Endocrinol Metab Clin North Am. 2017; 46(4):947-982.
• Vitamin D replacement in children, adolescents and pregnant women in the middle east and north africa: a systematic review and meta-analysis of randomized controlled trials.​​
  Chakhtoura M, Akl EA, El Ghandour S, Shawwa K, Arabi A, Mahfoud Z, Habib RH, Hoballah H, El-Hajj Fuleihan G. Metabolism 2017; 70:160 -176.
• CYP2R1 polymorphisms are important modulators of circulating 25-hydroxyvitamin D levels in elderly females with vitamin insufficiency, but not of the response to vitamin D supplementation.​
  Arabi A, Khoueiry-Zgheib N, Awada Z, Mahfouz R, Al-Shaar L, Hoteit M, Rahme M, Baddoura R, Halabi G, Singh R, El-Hajj Fuleihan G. Osteoporos Int. 2017; 28(1):279-290.
• Impact of Vitamin D Replacement in adults and elderly in the middle east and north africa: a systematic review and meta-analysis of randomized controlled trials.
  Chakhtoura M, Akl EA, El Ghandour S, Shawwa K, Arabi A, Mahfoud Z, Habib RH, Hoballah H, El-Hajj Fuleihan G. Osteoporos Int 2017; 28:35–46.
• The relationship between calciotropic hormones, IGF1, and bone mass across pubertal stages.​Matar M, Al-Shaar L, Maalouf J, Nabulsi M, Arabi A, Choucair M, Tamim H, El-Hajj Fuleihan G. J Clin Endocrinol Metabol 2016; 101(12):4860-4870.​
• Hypovitaminosis D in bariatric surgery: a systematic review of observational studies.
  Chakhtoura MT, Nakhoul NN, Shawwa K, Mantzoros C, El-Hajj Fuleihan G. Metabolism 2016; 65(4):574-85.
• Vitamin D in endometriosis: A causative or confounding factor?
  Sayegh L, El-Hajj Fuleihan G, Nassar A. Metabolism Clinical and Experimental 2014; 63:32-41.
• Hypovitaminosis D in a sunny country: Time trends, predictors, and implications for practice guidelines.
  Hoteit M, Al-Shaar L, Yazbeck C, Bou Sleiman M, Ghalayini T, El-Hajj Fuleihan G. Metabolism 2014; 63(9):68-978.
• Association between low vitamin D levels and the diagnosis of asthma in children: a systematic review of cohort studies.
  Rajabbik M, Tamara L, Alkhaled L, Fares M, El-Hajj Fuleihan G, Mroueh S, Akl E. Allergy, Asthma & Clinical Immunology 2014; 10(1):31.
• The role of vitamin D deficiency in the incidence, progression, and complications of type 1 diabetes mellitus.
  Chakhtoura M, Azar ST. Int J Endocrinol. 2013; 2013:148673.
  
• Hypovitaminosis D in patients with type 2 Diabetes Mellitus: Relation to disease control and complications.
  Hala Ahmadieh, Sami T Azar, Najla Lakkis, Asma Arabi. ISRN Endocrinol. 2013;2013:641098.​
• 25-Hydroxyvitamin D assay variations and impact on clinical decision making.
  Barake M., Daher RT., Salti I, Cortas NK., Al-Shaar L., Habib RH, and El-Hajj Fuleihan G. J Clin Endocrinol Metab 2012; 97(3):835-843.
• Parathyromatosis: a rare yet problematic etiology of recurrent and persistent hyperparathyroidism.
  Hage M, Salti I, El-Hajj Fuleihan G. Metabolism 2012; 61:762-775.
• Use of recombinant human parathyroid hormone in hypocalcemic cardiomyopathy.
  Ballane GT, Sfeir JG, Dakik HA, Brown EM, El-Hajj Fuleihan G. European Journal of Endocrinology/European Federation of Endocrine Societies 2012; 166(6):1113-20.
• PTH level but not 25 (OH) Vitamin D level Predicts Bone Loss rates in the Elderly.
  Arabi A, Baddoura R, El-Rassi R, El-Hajj Fuleihan G. Osteoporos Int 2012; 23:971-980.
• Vitamins and bone health: beyond calcium and vitamin D.
  Ahmadieh H, Arabi A. Nutr Rev 2011; 69(10):584-98.
• Effect of age, gender and calciotropic hormones on the relationship between vitamin D receptor gene polymorphisms and bone mineral density.
  Arabi A, Mahfoud Z, Zahed L, El-Onsi L, El-Hajj Fuleihan G. Eur J Clin Nutr 2010; 64(4):383-91.
• Age but not gender modulates the relationship between PTH and vitamin D.
  Arabi A, Baddoura R, El-Rassi R, El-Hajj Fuleihan G. Bone 2010; 47(2):408-12.
• Regression of skeletal manifestations of hyperparathyroidism with oral vitamin D.
  Arabi A, Khoury N, Birbari A, Zahed L, El-Hajj Fuleihan G. J Clin Endocrinol Metab. 2006; 91(7):2480-3.
• Hypovitaminosis D osteopathy: Is it mediated through PTH, lean mass, or is it a direct effect?
  Arabi A, Baddoura R, Awada H, Salamoun M, Ayoub G, El-Hajj Fuleihan G. Bone 2006; 39:268-275.
• There is no lower threshold for parathyroid hormone as 25 –hydroxyvitamin D concentration increases.
  Vieth R, El-Hajj Fuleihan G. J Endocrinol Invest 2005; 28:183-186.
• Low calcium and vitamin D intake in healthy adolescents and their correlates.
  Salamoun M, Kiizirian A, Tannous R, Deeb M, El-Hajj Fuleihan G. Eur J Clin Nutr 2005; 59:177-184.​
• Hypercalcemia in Langerhan cell granulomatosis with elevated calcitriol levels.
  El-Ali H, Abu Yabis A, Issa E, Salem Z, Tawil A,​ Khoury N, El-Hajj Fuleihan G. Bone 2002; 30:331-334.
• Hypovitaminosis D in healthy school children.
  El-Hajj Fuleihan G, Nabulsi M, Shoucair M, Salamoun M, Hajj-Shahine C, Kizirian A,Tannous R. Pediatrics 2001; 107:1-7.
• Effects of age and gender on PTH dynamics.
  Haden S, Stoll A, McCormick S, Scott J, El-Hajj Fuleihan G. Clinical Endocrinology 2000; 52:329-338.
• Nutritional osteomalacia: substantial clinical improvement and gain in bone density post-therapy.
  El-Ali Hussam, El-Hajj Fuleihan G. J Clin Densit 2000; 3:97-101.
• Calcium modulation of the renin aldosterone axis.
  Porter L, Conlin P, Scott J, Brown EM, El-Hajj Fuleihan G. J Endocrinol Investigation 1999; 22:115-21.
• Calcidiol and PTH levels in women attending an osteoporosis program.
  Haden ST, El-Hajj Fuleihan G, Angell JE, Cotran NM, LeBoff MS. Calcified Tissue Int 1999; 64:275-79.
• The effect of lithium on calcium-induced changes in adrenocorticotrophin levels.
  Haden ST, Stoll AL, McCormick S, Scott J, El-Hajj Fuleihan G. J Clin Endocrinol Metab 1999; 84:198-202.
• Calcium regulated renal calcium handling in healthy men: relationship to sodium handling.
  El-Hajj Fuleihan G, Seifter J, Scott J, Brown EM. J Clin Endocrinol Metab 1998; 83:2366-2372.
• Alterations in parathyroid dynamics in lithium-treated subjects.
  Haden ST, Stoll AL, McCormick S, Scott J, El-Hajj Fuleihan G. J Clin Endocrinol Metab 1997; 82:2844-48.
• The parathyroid hormone circadian rhythm is truly endogenous.
  El-Hajj Fuleihan G, Klerman EB, Brown EN, Choe Y, Brown EM, Czeisler CA. J Clin Endocrinol Metab 1997; 82:281-286.
• Calcium modulation of adrenocorticotropic hormone levels in women.
  El-Hajj Fuleihan G, Brown EM, Gleason R, Scott J, Adler GK. J Clin Endocrinol Metab 1996; 81:932-936.
• Racial differences in parathyroid hormone dynamics.
  El-Hajj Fuleihan G, Gundberg CM, Gleason R, Brown EM, Stomski ME Grant FD, Conlin PR. J Clin Endocrinol Metab 1994; 79:1642-1647 .
• Tertiary hyperparathyroidism during high phosphate therapy of familial hypophosphatemic rickets.
  Rivkees SA, El-Hajj Fuleihan G, Brown EM, Crawford JD. J Clin Endocrinol Metab 1992; 75:1514-1518.
• A comparison of the effects of concanavalin A and TPA on the modulation of parathyroid function by extra cellular calcium and neomycin in dispersed bovine parathyroid cells.
  Brown EM, Butters R, Katz C, Kifor O, El-Hajj Fuleihan G. Endocrinology 1992;130:3143-3151.
• Hypervitaminosis associated with drinking milk.
  Jacobus CH, Holick MF, Qing S,Chen TC, Holm I, Kolodny J, El-Hajj Fuleihan G, Seely EW. New Engl J Med 1992; 326:1174-76.
• Effects of the lectin concanavalin-A on the regulation of second messengers and PTH release in bovine parathyroid cells.
  El-Hajj Fuleihan G, Katz G, Kifor O, Gleason R, Brown EM. Endocrinology 1991; 128:2931-36.
• A comparison of the effects of divalent and trivalent cations on PTH release, CAMP accumulation, and the levels of inositol phosphates in bovine parathyroid cells.
  Brown EM, El-Hajj Fuleihan G, Chen CJ, Kifor O. Endocrinology 1990; 127:1064-71.
• Effect of the lectin con A on calcium regulated cAMP accumulation in bovine parathyroid cells.
  El-Hajj Fuleihan G, Brown EM. Endocrinology 1990; 126:1996-2002.
• Calcium dependent release of intact parathyroid hormone by human pathologic parathyroid tissue in vitro.
  El-Hajj Fuleihan G, Chen CJ, Rivkees SA, Marynick SP, Stock J Pallotta JA, Brown EM. J Clin Endocrinol Metab 1989; 69:860-7.
• Regulation of calcitropic hormones in vivo in the New Zealand white rabbit.
  Warren HB, Lausen GGN, Segre GV, El-Hajj Fuleihan GA​, Brown EM. Endocrinology 1989; 125:268-90.​
• Untreated thyrotoxicosis as a manifestation of anorexia nervosa.
  Rolla AR, El-Hajj Fuleihan G, Goldstein H. Am J Med 1986; 81:163-5.
  
  

Osteoporosis

• Parsimonious and Explainable Machine Learning for Predicting Mortality in Patients Post Hip Fracture Surgery.
  Trad F, Isber B, Yammine R, Hatoum K, Obeid D, Chahine M, Haidar R, El-Hajj Fuleihan G, Chehab A. Scientific Reports 2025 in press.
  
• Bone Effects of Anti-Cancer Treatments in 2024.​
  Teissonnière M, Point M, Biver E, Hadji P, Bonnelye E, Ebeling PR, Kendler D, Villiers TD, Holzer G, Body JJ, El Hajj Fuleihan G, Brandi ML, Rizzoli R, Confavreux CB. Review Calcif Tissue Int. 2025 Mar 27;116(1):54. doi: 10.1007/s00223-025-01362-0.
  
• Secular Trends in Hip Fracture Mortality and Predictors of Mortality from the NSQIP Database. 
  Rhayem C, Ghosn A, Issa ZA, Alwan JS, Dimassi H, Haidar R, El-Hajj Fuleihan G. The Journal of Clinical Endocrinology & Metabolism, 2025, 00, 1–10.
  
• Prevalence of Incomplete Atypical Femoral Fractures Using Single Energy Absorptiometry after Long Term Anti-resorptive Therapy.​
  Abou Chaaya J, El-Hajj Fuleihan G, Cheung AM, Abou Layla H, Arabi A. JBMR 2024; 1-9.
  
• Prevalence and Risk Factors for AFF among Lebanese Patients with Hip and Shaft Fractures.​
  Bou Khalil A, Yammine R, Rameh V, Zadeh C, Saad R, Mallah H, Khoury NJ, El-Hajj Fuleihan G. JBMR Plus 2024; 8(8).
  
• Effect of antiresorptive therapy on aromatase inhibitor induced bone loss in postmenopausal women with early-stage breast cancer: A systematic review and meta-analysis of randomized controlled trials.
  Bassatne A, Bou Khalil A, Chakhtoura M, Arabi A, Van Poznak C, El-Hajj Fuleihan G. Metabolism Clinical and Experimental 2022; 128:154962.
  
• ​Systematic review of major osteoporotic fracture to hip fracture incidence rate ratios worldwide: implications for Fracture Risk Assessment Tool (FRAX)-derived estimates.
  Chakhtoura M, Dagher H, Sharara S, Ajjour S, Chamoun N, Cauley J, Mahfoud Z, Boudreau R, El-Hajj Fuleihan G. JBMR 2021; 36(10):1942-1956.
• ​​Osteoporotic hip and vertebral fractures in the Arab region: a systematic review.​
  Barake M, El Eid R, Ajjour S, Chakhtoura M, Meho L, Mahmoud T, Atieh J, Sibai AM, El-Hajj Fuleihan G. Osteoporos Int. 2021; 32(8):1499-1515.​
• Disease burden of osteoporosis and other non-communicable diseases in lebanon.​​
  
  Bassatne A, Harb H, Jaafar B, Romanos J, Ammar W, El-Hajj Fuleihan G. Osteoporos Int. 2020; 31(9):1769-1777.
  
• Management of hip fractures at an academic center: challenges and opportunities.​
  Saad R, Beydoun M, El-Hajj Fuleihan G. J Clin Densitom 2020; 23(4):524-533.​
  
• Secular trends of hip fractures in lebanon 2006 – 2017: implications for clinical practice and public health policy in the middle east region.
  Saad S, Harb H, Bou-Orm I, Ammar W, El-Hajj Fuleihan G. JBMR 2019; 35(1):71-80.
• Management of osteoporosis in the middle east and north africa: a survey of physicians’ perceptions and practices.
  Salem A Beshyah, Yousef Al-Saleh, Ghada El-Hajj Fuleihan. Arch Osteoporos 2019; 14(1):60.
• Diagnosis and management of bone fragility in diabetes: an emerging challenge.​
  ​​Ferrari SL, Abrahamsen B, Napoli N, Akesson K, Chandran M, Eastell R, El-Hajj Fuleihan G, Josse R, Kendler DL, Kraenzlin M, Suzuki A, Pierroz DD, Schwartz AW, Leslie WD. Osteoporos Int 2018; 29(12):2585-2596.
  
• Effects of growth hormone therapy on bone density and fracture risk in age-related osteoporosis in the absence of growth hormone deficiency: a systematic review and meta-analysis.​​
  ​Barake M, Arabi A, Nakhoul N, El-Hajj Fuleihan G, El Ghandour S, Klibanski A, Tritos NA. Endocrine 2018; 59(1):39-49.
  
• Worldwide fracture prediction.
  El-Hajj Fuleihan G, Chakhtoura M, Cauley J, Chamoun N. J Clin Densitom 2017; 20(3):397-424.
  
• Worldwide prevalence and incidence of osteoporotic vertebral fractures.​​
  Ballane G, Cauley J, Luckey MM, El-Hajj Fuleihan G. Osteoporos Int 2017; 28:1531-1542.
  
• Predictors of trabecular bone score in school children.​
  Shawwa K, Arabi A, Nabulsi M, Maalouf J, Salamoun M, Choucair M, Hans D, El-Hajj Fuleihan G. Osteoporos int 2016; 27:703-710.
  
• MECHANISMS IN ENDOCRINOLOGY: Mechanisms and evaluation of bone fragility in type 1 diabetes mellitus.​
  Hough FS, Pierroz DD, Cooper C, Ferrari SL, K Akesson, B Abrahamsen, Ardawi MSM, Chandran M, Cooper C, Eastell R, El Hajj Fuleihan G, Josse R, Kendler D, Kraenzlin M, Leslie W, Massi Benedetti M, Mithal A, Napoli N, Schwartz A, Suzuki A. European Journal of Endocrinology 2016; 174(4):R127–R138.
  
• Bone loss in obesity and obstructive sleep apnea: a review of literature.​
  Chakhtoura M, Nasrallah M, Chami H. J Clin Sleep Med. 2015; 11(4):575-80.
  
• Obstructive sleep apnea and osteoporosis risk. reply to letter to the editor.​​
  Chakhtoura M, Nasrallah M, Chami H. J Clin Sleep Med. 2015; 11(9):1071-2.
  
• Impact of changes in mortality on FRAX-derived fracture.
  Kreidieh OI, El-Hajj Fuleihan G. Bone 2014; 62:43–50.
  
• Secular trends in hip fractures worldwide: opposing trends East versus West.​
  Ballane G, Cauley J, Luckey M, El-Hajj Fuleihan G. JBMR 2014; 29(8):1745-1755.
• Dual-energy x-ray absorptiometry interpretation and reporting in children and adolescents: the revised 2013 ISCD pediatric official positions.
  Crabtree NJ, Arabi A, Bachrach LK, Fewtrell M, El-Hajj Fuleihan G, Kecskemethy HH, Jaworski M, Gordon CM. J Clin Densitom. 2014; 17:225-42.
  
• Heritability of musculoskeletal parameters and body composition variables during adolescence.​
  Nabulsi M, Mahfoud Z, Al Shaar L, El-Rassi R, Maalouf J, and El-Hajj Fuleihan G. J Clin Densitom 2013; 16(2):223-30.
  
• Incretin based therapies: bone protective effects.
  Chakhtoura M, Azar ST. Endocr Metab Immune Disord Drug Targets. 2013; 13(4):289-94.
  
• Proton pump inhibitors have no measurable effect on calcium and bone metabolism in healthy young males: a prospective matched controlled study.​​
  Sharara A, El-Halabi M, Ghaith O, Habib R, Mansour N, Malli A, and El-Hajj Fuleihan G. Metabolism 2013; 62(4):518-26.
  
• Making the first fracture the last fracture: asbmr task force report on secondary fracture prevention.​
  Eisman JA, Bogoch ER, Dell R, Harrington JT, McKinney RE Jr, McLellan A, Mitchell PJ, Silverman S, Singleton R, Siris E; ASBMR Task Force on Secondary Fracture Prevention. Collaborators: Eisman JA, Siris ES, Adler R, Akesson K, Amling M, Baim S, Bavonratanavech S, Bianchi ML, Bilezikian J, Budhiparama NC, Center JR, Chevalley T, Clark P, Cooper C, Diez-Perez A, Edwards BJ, Foldes AJ, Fuleihan Gel-H, Geusens P, Ha YC, Hagino H, Do PH, Johnson ML, Kung AW, Langdahl BL, Lau E, Le AT, LeBoff MS, Lee JK, Lems WF, Ling X, de Castro Machado AB, Magaziner J, Malhotra R, Marsh D, Masri B, Mascarenhas MR, Meyer HE, Mittal A, Moon KH, Moon SH, Newman ED, Tong P, Recker RR, Adolfo J, Portales R, Saag KG, Seibel MJ, Schelkun SR, Solomon DH, Stepan JJ, Stolnicki B, Wang BB, Won YY, De Vernejoul MC, Yang KH, Yue D, Yoon HK. J Bone Miner Res. 2012; 27(10):2039-46.
  
• Predictors of bone loss in childhood malignancies: a prospective study.​
  El-Hajj Fuleihan G, Muwakkit S, Arabi A, El-Onsi Daouk L, Ghalayini T, Abboud M. Osteoporos Int 2012; 23:665–674.
  
• Osteoporosis fractures, DXA, and fracture risk assessment: meeting future challenges in the eastern mediterranean region.​​
  Baddoura R, Hoteit M, El-Hajj Fuleihan G. J Clin Densitom 2011; 14(4):384-94.
  
• Official Positions for FRAX Clinical Regarding International Differences.From Joint Official Positions Development Conference of the International Society for Clinical Densitometry and International Osteoporosis Foundation on FRAX.
  Cauley JA, El-Hajj Fuleihan G, Arabi A, Fujiwara S, Ragi-Eis S, Calderon A Chionh SB, Chen Z, Curtis JR, Danielson ME, Hanley DA, Kroger H, Kung AWC, Lesnyak O, Nieves J, Pluskiewicz W, El Rassi R, Silverman S, Schott AM, Rizzoli R, Luckey M. Journal of Clinical Densitometry 2011; 14(3) 240-262.
  
• Hip fracture incidence in Lebanon: A national registry based study with reference standardized rates worldwide.​
  Sibai A, Nasser W, Ammar W, Khalifeh M, Harb H, El-Hajj Fuleihan G. Osteoporos Int 2011; 22:2499-2506.
  
• The impact of zoledronic acid on regenerate and native bone after consolidation and removal of the external fixator: An animal model study.
  Saghieh S, Khoury NJ, Tawil A, Masrouha KZ, Musallam KM, Khalaf K, Dosh L, Jaouhari RR, Birjawi G, El-Hajj Fuleihan G. Bone 2010; 46:363-8.​
  
• Risk estimates for hip fracture from clinical and densitometric variables and impact of database selection in lebanese subjects.​​
  ​Badra M, Mehio-Sibai A, Al-Hazzouri AZ, Naja HA, Baliki G, Salamoun M, Afeiche N, Baddoura O, Bulos S, Haidar R, Lakkis S, Musharrafieh R, Nsouli A, Taha A, Tayim A, El-Hajj Fuleihan G. J Clin Densitom 2009; 12(3):272-8.
  
• Modeling pathways for low bone mass in children With malignancies.​​​
  Chaiban J, Muwakkit S, Arabi A, Jomaa L, Onsi-Daouk L, El-Rassi R, Abboud M, and El-Hajj Fuleihan G. Journal of Clinical Densitometry: Assessment of Skeletal Health 2009; 12(4):441-449.
• Negative effect of leptin on bone mass in type 1 diabetes.
  Kassem HS, Arabi A, Zantout MS, Azar ST. Acta Diabetol. 2008;45(4):237-41.
• Predictors of bone density in ambulatory patients on antiepileptic drugs.
  El-Hajj Fuleihan G, Dib L, Yamout B, Sawaya R, Mikati M. Bone 2008; 43:149-155.
• How effective is risedronate in preventing bone loss in patients on high-dose steroids?
  Arabi A, El-Hajj Fuleihan G. Nat Clin Pract Endocrinol Metab 2008; 4(10):540-1.
• Discriminative ability of dual-energy x-ray ‎absorptiometry site selection in identifying patients with osteoporotic ‎fractures.​
  Arabi A, Baddoura R, Awada H, Khoury N, Hadda-zebouni S, Ayoub G, El-Hajj Fuleihan G. Bone 2007; 40(4):1060-5.
• Vertebral fracture risk and impact; of database selection on identifying elderly with osteoporosis.
  Baddoura R, Arabi A, Haddad-Zebouni S, Khoury N, Salamoun M, Ayoub G, Awada H, El-Hajj Fuleihan G. Bone 2007; 40(4):1066-72.
• ​Leptin effect on bone: is it ethnic specific?
  Arabi A. J Lab Clin Med 2005; 146:7-8.
• Benefits of pamidronate in children with osteogenesis imperfecta: a prospective study.​
  Forin V, Arabi A, Guigonis V, Filipe G, Bensman A, Roux C. Joint Bone Spine 2005; 72:313-318.
• Impact of densitometer on risk assessment for osteoporosis.
  Arabi A, Salamoun M, Ballout H, El-Hajj Fuleihan G. J Clin Densitometry 2005; 8:261-266.
• Impact of anthropometric, lifestyle and body composition variables on ultrasound measurements in healthy children.​
  Dib L, Arabi A, Nabulsi M, Maalouf J, El-Hajj Fuleihan G. Bone 2005; 36:736-742.
• High plasma leptin level is not associated with higher bone mineral density in hyperinsulinemic premenopausal women.​
  Abou Samra R, Hwalla Baba N, Torbay N, Dib L, El-Hajj Fuleihan G. J Clin Endocrinol Metab 2005; 90:2588-2594.
• Sex differences in the effect of body-composition variables on bone mass in healthy children and adolescents.
  Arabi A, Tamim H, Nabulsi M, Maalouf J, Khalife H, Shoucair M, Veith R, El-Hajj Fuleihan G. Am J Clin Nutr 2004; 80:1428-1435.
• Hip fractures in Lebanese patients: determinants and prognosis.
  Hreybeh H, Salamoun M, Badra M, Afeiche N, Baddoura O, Boulos S, Haidar R, Lakkis R, Musharafieh R, Nsouli A, Taha A, Tayim A, El-Hajj Fuleihan G. J Clin Densitom 2004; 7:368-375.
• Safety and efficacy of risedronate in reducing fracture risk in osteoporotic women 80 years of age and older: Implications for the use of antiresorptive drugs in the old and the oldest old.
  Boonen S, McClung M, Eastell R, El-Hajj Fuleihan G, Barton I, Delmas P. J Am Geriatr Soc 2004; 52:1832-1839.
• Patients with osteoporosis prefer once weekly to daily dosing with alendronate.
  Kendler D, Kung AW, El-Hajj Fuleihan G, González González JG, Gaines KA, Verbruggen N, Melton ME.​ Maturitas 2004; 48:243-251.
  
• Bone mineral metabolism and density in patients on dialysis.​
  Zayour D, Daouk M, Salamoun M, Medawar W, El-Hajj Fuleihan G. Transplant Proc 2004; 36:1297-1301.
  
• Bone mineral density by age, gender, pubertal stages and socioeconomic status in healthy lebanese children and adolescents.​
  Arabi A, Nabulsi M, Maalouf J, Shoucair M, Khalife H, Vieth R, El-Hajj Fuleihan G. Bone 2004; 35:1169-1179.
  
• Serum leptin as a determinant of bone resorption in healthy postmenopausal women​.
  Roux C, Arabi A, Porcher R, Garnero P. Bone 2003; 33:847-52.
  
• Effect of gender, puberty, and vitamin D status on biochemical markers of bone remodeling.​
  Eid-Fares J, Shoucair M, Nabulsi M, Salamoun M, Hajj-Shahine M, El-Hajj Fuleihan G. Bone 2003; 33:242-247.
  
• Body composition changes during hormone replacement therapy: A two-year prospective study. 
  Arabi A, Garnero P, Porcher P, Pelissier C, Benhamou C, Roux C. Hum Reprod 2003; 18:1747-52.
• Low peak bone mineral density in healthy Lebanese subjects.
  El-Hajj Fuleihan G, Baddoura R, Awada H, Salam N, Salamoun M, Rizk P. Bone 2002; 31:520-8.
  
• Efficacy and tolerability of cyclical intravenous pamidronate in patients with low bone mass.
  Younis H, Farhat G, El-Hajj Fuleihan G. J Clin Densitom 2002; 5(2):1-7.
  
• Bone density reporting in the United States: a national survey.​​
  El- Hajj Fuleihan G, Stock J, Saifi G, McClung M. J Clin Densitom 2002; 5:1-7.
  
• Les rhumatologues et la DHEA.
  Arabi A, Roux C. La Letter Du Rhumatologue 2001; 276: 20-25.
• Longitudinal changes in bone density in hyperparathyroidism.
  El-Hajj Fuleihan G. Moore F, Testa M, LeBoff M, Angell J, Scott J. J Clin Densitometry 1999; 2(2):153-162.
• Modeling fracture risk using bone density age, and years since menopause.​​
  Carroll J, Testa MA, Erat K, LeBoff MS, El-Hajj Fuleihan G. Am J Preventive Med 1997; 13:447-452.
• Reproducibility of DXA absorptiometry: A model for bone loss estimates.​
  El-Hajj Fuleihan G, Testa MA, Angell JE, Porrino N, LeBoff MS. J Bone Miner Res 1995; 10:1004-1014.​
• Dual x-ray absorptiometry of the forearm: reproducibility and correlation with single photon absorptiometry.​
  LeBoff MS, El-Hajj Fuleihan G, Angell JE, Chung S, Curtis K. J Bone Miner Res 1992; 7:841-46.
• Low dose prednisone does not affect calcium homeostasis or bone density in post menopausal women with rheumatoid arthritis.​​
  LeBoff MS, Wade JP, Mackowiack S, El-Hajj Fuleihan G, Zangari Liang H. J Rheumatology 1991; 18:339-44.
  

Case Report

• ​​Thyroiditis After Parathyroidectomy.
  Kwayess R, Cooper DS, El-Hajj Fuleihan G. JCEM Case Rep 2024; 2(2):1-12.​​
• Hyperphosphatemic familial tumoral calcinosis secondary to fibroblastgrowth factor 23 (FGF23) mutation: a report of two affected familiesand review of the literature.
  Chakhtoura M, Ramnitz MS, Khoury N, & Nemer G, Shabb N, Abchee A, Berberi A, Hourani M, Collins M, Ichikawa S, El-Hajj Fuleihan G. Osteoporosis International 2018; 29:1987-2009.
• Cushing syndrome due to ectopic ACTH secretion presenting with lower limb edema and pulmonary nocardia infection: case report and review of the literature.
  El Hayek MS, Shoucair M, Arabi A. J Endocrinol Metab 2016; 6:158-161.  
• Papillary carcinoma arising in a thyroglossal duct cyst 2 Case reports and review of the literature.​​​
  Arabi A, Zayour D, Salti I. International Surgery 2007; 92(6):327-330.
• Hypercalcemia and diabetes; insipidus in a patient previously treated with lithium for 20 years.
  Khairallah W, Fawwaz A, Brown EM, El-Hajj Fuleihan G. Nature Clinical Practice Nephrology 2007; 3(7):397-404.
  
  

Genetics

• The Genetic Architecture of Vitamin D Deficiency among an Elderly Lebanese Middle Eastern Population: An Exome-Wide Association Study.​
  Hendi NN, Chakhtoura M, Al-Sarraj Y, Basha DS, Albagha O, El-Hajj Fuleihan G, Nemer G. Nutrients 2023; 15:3216.
  
• High prevalence of metabolic syndrome in patients with psoriasis in Lebanon: a prospective study.
  Salam I, Asma A, Dana H, Abdul-Ghani K. Int J Dermatol 2016; 55(4):390-5.
• Bibliometric trends in ophthalmology 1997-2009.
  Mansour A, Mollayess G, Habib R, Arabi A, Medawwar W. Indian Journal of Ophthalmology 2015; 63:54-8.
  
• Estrogen receptor α is not a candidate gene for metabolic syndrome in caucasian elderly subjects.​​
  Hoteit M, Arabi A, Habib R, Mahfouz R, Baddoura R, MD, Halaby G, El-Hajj Fuleihan G. Metabolism 2014; 63(1):50-60.
  
• Vitamin D receptor gene polymorphisms modulate the skeletal response to vitamin D supplementation in healthy girls.​​
  Arabi A, Zahed L, Mahfoud Z, El-Onsi L, Nabulsi M, Maalouf J, El-Hajj Fuleihan G. Bone 2009; 45(6):1091-1097.

Other Topics

• Streamlining Systematic Reviews with Large Language Models Using Prompt Engineering and Retrieval Augmented Generation.​​
  Trad F, Yammine R, Charafeddine J, Chakhtoura M, Rahme M, El-Hajj Fuleihan G, Chehab A. BMC Med Res Methodol 2025; 10;25(1):130.
  

• Accelerating Systematic Reviews Via Natural Language Processing.
  Nasser F, Trad F, Chakhtoura M, El-Hajj Fuleihan G, Chehab A. Poster and paper 2024 International Conference on Computer and Applications (ICCA), Cairo, Egypt 2024:1-11. doi:10.1109/ICCA62237.2024.10927953.

• Development, Reproducibility and Validity of the Modified Mediterranean Prime Screen Among Women of Reproductive Age in Lebanon.​
  Assaad M, Ajjour S, Rahme M, Al-Shaar L, Sakr M, Ghattas H, El-Hajj Fuleihan G, Jabbour J. Br J Nutr. 2024; 31:1-23. 
  

• Effect of young age (below 40 years) on oncologic outcomes in Lebanese patients with breast cancer: a matched cohort study.
  Sbaity E, Tamim H, El-Hajj Fuleihan G, Abbas J, Zahwe M, El Sayed R, Shamseddine A. BMC Cancer 2024; 24:560.​
  

• Immunotherapy in the management of COVID-19 and risk of secondary infections: A systematic review and meta-analysis.​
  Kabbani D, Sonpar A, Weyant B, Lau K, Campbell S, Lotfi M, Chakhtoura M, Akl E, Cervera C. Open Forum Infect Dis. 2023; 10(1):ofac655.
  

• Team-Based Learning to Teach Critical Appraisal to Large Classes of Medical Students.​
  Daou D, Chakhtoura M, El-Yazbi A, Mukherji D, Sbeity E, Refaat M, Nabulsi M. BMC Med Educ. 2022;22(1):77.

• Research fellowship in a Lebanese medical school: what does it take to shift from an informal to a formal program?​
  Chakhtoura M, Salim Karam E, Akl EA, El Rassi R, Honein-Abou Haidar G. Plos One 2022; 17(12):e0278576. 
  

• Association between substance use disorders and self‐ and other‐directed aggression: An integrated model approach.
  Ghossoub E, Adib S, Maalouf F, El-Hajj Fuleihan G, Tamim H, Nahas Z. Aggressive Behavior 2019;1–10.        

• Disease free survival of well differentiated thyroid cancer: 20 year experience at a tertiary care center in lebanon.
  Hajj Boutros R, Arabi A, Shoucair M, Abbas J, Salti I. International Archives of Medicine, Section Endocrinology 2018; 11(4):1755-7682.

• Painful and prolonged muscle cramps following insulin injections in a patient with type 2 diabetes mellitus: revisiting the 1992 duke case.
  Ballout RA, Arabi A. Front Endocrinol. 2017; 8:243.​
  

• Thyroid fine-needle aspiration under ultrasound guidance: experience from an academic tertiary care center in lebanon. 
  Hajj Boutros R, Haddad M, Boulos F, Arabi A. international archives of medicine section. Endocrinology 2017; 10(162):1755-7682.

• Continuous positive airway pressure and type 2 diabetes mellitus.
  Chakhtoura M, Azar ST. Diabetes Metab Syndr. 2012; 6(3):176-9.

• Outcome of thyroid associated ophthalmopathy treated by radiation therapy.
  Abboud M, Arabi A, Salti I, Geara F. Radiat Oncol 2011;13(6):46.​​​
  

• Seasonal variations of glucose control in Lebanese patients with type 1 diabetes.
  El Baba Kh, Zantout M, Arabi A, Azar S. Biol Rhythm ​Res. 2010; 41:91-97.​
  ​